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MCT1 is mainly located in slow twitch muscle fibers and is regarded responsible for the influx of lactate to the high oxidative muscles, whereas MCT4 is mainly located in fast muscle fibers and is respon- sible for outflux of lactate from cells. The current data indicate that the amount of MTC4 is low in blood cells, which leads to a smaller outflux of lactate from the blood during recovery than the influx of lactate to the blood during high intensity exercise.
Nevertheless, the understanding of lactate removal after high-intensity exercise during whole-body exercise requires further examination. Modeling in human biology is always a challenge since one is confronted with con- ceiving a simple, yet realistic representation of complex phenomena occurring at differ- ent levels cells, organs, tissue.
The parameters used in the current study will, in principle, be dependent on the exercise mode employed; fitness level of the individual tested and is only applicable for fixed concentrations of glycogen e.
Thus, to construct valid simulation models of lactate concentration during dynamic exercise these need to be developed for each individual.
Funding No sources of funding. Box 25, Kjeller, Norway. Both authors contributed similarly with important intellectual content and in drafting, revising and finishing the manuscript.
All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Schmidt-Nielsen K: Animal Physiology: adaptation and environment.
Cambridge: Cambridge University Press; Margaria R, Cerretelli P, Mangili F: Balance and kinetics of anaerobic energy release during strenuous exercise in man.
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Biochem Soc Trans , Brooks GA: Link between glycolytic and oxidative metabolism. Myers J: Dangerous curves: a perspective on exercise, lactate, and the anaerobic threshold. Chest , Juel C: Lactate-proton cotransport in skeletal muscle. Physiol Rev , Am J Physiol ,